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Other medications that may be administered via rectal suppository hydrocortisone mesalazine for the treatment of inflammatory bowel disease (IBD) bisacodyl or glycerol for constipation promethazine or ondanestron for nausea and vomiting certain pain medications, such as ibuprofen or oxycodone Leakage of the medication, as well as personal pain and discomfort, are all possible side effects associated with rectal suppositories